The producer, consumer, and environmental impacts of a counterfactual of ShB-resistant rice production were calculated using data from U.S. county-level rice production in the Mid-South and simulated Sheath Blight (ShB) infection and yield-loss rates. Results indicate a $43 million increase in consumer surplus via ShB alleviation, with enough additional rice produced to feed 1.7 million people. A life cycle assessment (LCA) also shows that the counterfactual has lower environmental impacts than the status quo of ShB-prone rice production. These estimates provide important economic and environmental information to donors, policy makers, and breeding programs globally on the importance of increasing and maintaining genetic disease resistance.